6533b7d0fe1ef96bd125a2db
RESEARCH PRODUCT
Evidence of a 1,4-dipole intermediate in the reaction of 1-phenyl-4-vinylpyrazole with ptad
Mercedes Medio SimónJosé Sepúlveda-arquessubject
chemistry.chemical_classificationBicyclic moleculeOrganic ChemistryAzetidineReaction intermediateBiochemistryMedicinal chemistryChlorideAdductchemistry.chemical_compoundchemistryYlideDrug DiscoveryAcetonemedicineOrganic chemistryMethylenemedicine.drugdescription
Abstract 1-Phenyl-4-vinylpyrazole reacts with 1-phenyl-1,2,4-triazoline-3,5-dione in methylene chloride to form an unstable azetidine (4). An intermediate 1,4-dipole is probably involved since, when the reaction is conducted in acetone, a 1:1:1 adduct (3) is isolated.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1985-01-01 | Tetrahedron Letters |