6533b7d0fe1ef96bd125a428
RESEARCH PRODUCT
Immune ambivalence: The schizophrenic bleomycin.
Hélène BugautGrégoire MignotFrançois Ghiringhellisubject
T cellImmunologyBleomycinregulatory T cellschemistry.chemical_compoundImmune systemimmunogenic cell deathmedicineImmunology and AllergyCytotoxic T cellAuthor's Viewtransforming growth factor betabiologybusiness.industryTransforming growth factor betamedicine.anatomical_structuremouse studyOncologychemistryCancer cellImmunologyCancer researchbiology.proteinImmunogenic cell deathbusinessbleomycineTransforming growth factordescription
In addition to cytotoxic effects, anticancer agents can exert multiple immunomodulatory functions. We have recently described the molecular mechanisms whereby bleomycin can 1) promote endoplasmic reticulum stress, causing the immunogenic death of cancer cells and hence strengthening antitumor CD8+ T cell responses; and 2) induce the secretion of transforming growth factor β (TGFβ), which stimulates regulatory T cells. This suggests that bleomycin may be favorably combined with TGFβ-targeting strategies.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2013-09-01 | Oncoimmunology |