6533b7d0fe1ef96bd125a482

RESEARCH PRODUCT

Optically active titanium complexes containing a tridentate linked amido-cyclopentadienyl ligand

Sabine VerchThomas P. SpaniolJun OkudaRainer Stürmer

subject

PharmacologyLigandOrganic ChemistryCenter (category theory)chemistry.chemical_elementOptically activeCatalysisAnalytical Chemistrychemistry.chemical_compoundCrystallographychemistryCyclopentadienyl complexDrug DiscoveryOrganic chemistryChirality (chemistry)Single crystalSpectroscopyAcetophenoneTitanium

description

Optically active titanium complexes Ti{η5:η1-C5R4SiMe2NC6H10 (OCH2Ph)-2}Cl2 (R = H, Me), containing a cyclopentadienyl ligand linked to the chiral trans-2-benzyloxycyclohexylamido group, were synthesized and characterized in both enantiomerically pure forms. A single crystal X-ray structure analysis of (−)-(R,R)-Ti{η5:η1-C5H4SiMe2NC6H10(OCH2Ph)-2}Cl2 shows a structure in which the benzyloxy group in the amido sidechain is not interacting with the titanium center. Upon activation with n-butyllithium, these complexes hydrogenate acetophenone N-benzylimine with low enantioselectivity. Chirality 12:472–475, 2000. © 2000 Wiley-Liss, Inc.

yearjournalcountryeditionlanguage
2000-05-29Chirality
https://doi.org/10.1002/(sici)1520-636x(2000)12:5/6<472::aid-chir30>3.0.co;2-q