6533b7d0fe1ef96bd125a497

RESEARCH PRODUCT

In Vitro Antioxidant Activity and In Vivo Topical Efficacy of Lipid Nanoparticles Co-Loading Idebenone and Tocopheryl Acetate

Ludovica Maria SantagatiConcetta Maria MessinaLucia MontenegroSimona ManuguerraRosaria ArenaLorella PasquinucciCarmela ParentiAndrea SantulliRita Turnaturi

subject

antioxidantAntioxidantDPPHmedicine.medical_treatment02 engineering and technologylipid nanoparticlesPharmacologytocopheryl acetatemedicine.disease_causelcsh:Technology030226 pharmacology & pharmacylcsh:Chemistry03 medical and health scienceschemistry.chemical_compoundphoto-protective effect0302 clinical medicineIn vivoSolid lipid nanoparticlemedicineIdebenoneGeneral Materials Scienceskin hydrationlcsh:QH301-705.5InstrumentationFluid Flow and Transfer ProcessesIdebenonelcsh:TChemistryProcess Chemistry and TechnologyGeneral EngineeringIn vitro toxicologytopical administrationlipid nanoparticle021001 nanoscience & nanotechnologylcsh:QC1-999kin hydrationComputer Science Applicationsantioxidantslcsh:Biology (General)lcsh:QD1-999Idebenone; tocopheryl acetate; lipid nanoparticles; antioxidants; topical administration; skin hydration; photo-protective effectlcsh:TA1-2040Tocopheryl acetatelcsh:Engineering (General). Civil engineering (General)0210 nano-technologylcsh:PhysicsOxidative stressmedicine.drug

description

Idebenone (IDE) is a strong antioxidant that has been proposed for the treatment of skin disorders, including skin ageing. Unfavorable physico-chemical properties make IDE a poor skin permeant where effectiveness could be improved by its loading into suitable delivery systems such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC). In this work, we designed novel IDE-loaded NLC containing tocopheryl acetate (VitE) as a liquid component to obtain a synergic effect between IDE and VitE. The resulting NLC showed small particle sizes (24&ndash

yearjournalcountryeditionlanguage
2019-02-27Applied Sciences
https://doi.org/10.3390/app9050845