6533b7d0fe1ef96bd125a4c3

RESEARCH PRODUCT

Determination of Synchronization of Electrical Activity in the Heart by Shannon Entropy Measure

Flavia RavelliMichela MasèRenzo AntoliniLuca FaesGiandomenico Nollo

subject

Time delaysSeries (mathematics)business.industryAtrial fibrillationTime resolutionPattern recognitionmedicine.diseaseMeasure (mathematics)SynchronizationEngineering (all)medicine.anatomical_structureControl theorySettore ING-INF/06 - Bioingegneria Elettronica E InformaticamedicineRight atriumStatistical dispersionArtificial intelligencebusinessMathematics

description

In this paper we propose a new index of synchronization for the study of heart’s electrical activity during atrial fibrillation (AF). The index relies on the measure of the time delays between correspondent activations in two atrial electrograms and on the characterization of their dispersion by a measure of Shannon Entropy. The algorithm was validated on simulated signals mimicking different degree of synchronization. Results showed the index was able to discriminate among different levels of organization, provided that it works on series of at least 50 activations (time resolution of almost 10 sec during AF). Moreover, we applied the algorithm to real bipolar electrograms, obtained from a multipolar basket catheter in right atrium in two patients during atrial fibrillation: this showed the index able to distinguish different levels of complexity in AF.

yearjournalcountryeditionlanguage
2005-01-01
https://doi.org/10.1016/b978-008044648-6.50038-0