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RESEARCH PRODUCT
Ventricular-vascular coupling in hypertension: methodological considerations and clinical implications.
Ps SabaM CameliG CasalnuovoMm CicconeA GanauM MaielloPa ModestiMl MuiesanS NovoP PalmieroGd SannaP SchicchitanoRoberto Pedrinelli On Behalf Of The Working Group On Hypertension Prevention Rehabilitation Of The Italian Society Of Cardiologysubject
Ventricular-vascular couplingmedicine.medical_specialtyWave reflectionHeart VentriclesLeftDiastoleBlood PressureLeft ventricular hypertrophyPulse wave analysisVentricular Function LeftInput impedanceVascular StiffnessEffective arterial elastanceInternal medicinemedicineVentricular FunctionHumansArterial stiffness; Effective arterial elastance; Hypertension; Input impedance; Left ventricular hypertrophy; Pulse wave analysis; Therapy; Ventricular-vascular coupling; Wave reflection; Aorta; Arteries; Blood Pressure; Elasticity; Heart Ventricles; Humans; Hypertension; Vascular Stiffness; Ventricular Function Left; Cardiology and Cardiovascular Medicine; Medicine (all)AortaArterial structureVentricular functionbusiness.industryMedicine (all)Left ventricular hypertrophyarterial stiffness effective arterial elastance hypertension input impedance left ventricular hypertrophy pulse wave analysis therapy ventricular–vascular coupling wave reflectionGeneral MedicineArteriesmedicine.diseaseArterial stiffnessSettore MED/11 - Malattie Dell'Apparato CardiovascolareArterial treeElasticitymedicine.anatomical_structureVentricleHypertensionCardiologyTherapybusinessCardiology and Cardiovascular MedicineVentricular vascular couplingdescription
The present review is addressed to analyse the complex interplay between left ventricle and arterial tree in hypertension. The different methodological approaches to the analysis of ventricular vascular coupling in the time and frequency domain are discussed. Moreover, the role of hypertension-related changes of arterial structure and function (stiffness and wave reflection) on arterial load and how ventricular-vascular coupling modulates the process of left ventricular adaptation to hypertension are analysed.The different interplay between vascular bed and left ventricle emerges as the pathophysiological basis for the development of the multiple patterns of ventricular structural adaptation in hypertension and provides a pathway for the interpretation of systolic and diastolic functional abnormalities observed in hypertensive patients. Targeting the therapeutic approach to improve ventricular-vascular coupling may have relevant impact on reversing left ventricular hypertrophy and improving systolic and diastolic dysfunction.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-01-01 | Journal of cardiovascular medicine (Hagerstown, Md.) |