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RESEARCH PRODUCT
Collagen ultrastructure in ruptured cruciate ligaments
Markus F. NeurathE. Stofftsubject
AdultMaleMicroscopy Electron Scanning TransmissionPathologymedicine.medical_specialtyTime FactorsAdolescentAnterior cruciate ligamentmacromolecular substancesFibrillaw.inventionExtracellular matrixlawmedicineHumansOrthopedics and Sports MedicineElectron microscopicRupturebusiness.industryAnterior Cruciate Ligament InjuriesAnatomyMiddle Agedmedicine.anatomical_structureRepair tissueEvaluation Studies as TopicMicroscopy Electron ScanningUltrastructureLigamentWounds and InjuriesFemaleSurgeryCollagenElectron microscopebusinessdescription
The ultrastructure of collagen fibrils was investigated in normal (n 39) and ruptured (n 23) human anterior cruciate ligaments. The normal ligament had a complex three-dimensional structure. Collagen fibrils predominantly had a unidirectional course with parallel arrangement and a mean diameter of 75 (20-185) nm. Four days after anterior cruciate ligament rupture, the mean fibril diameter was increased; it later decreased, probably due to synthesis of young, thin 30-40 nm fibrils. Interfibrillar dysplastic collagen fibrils were detected in the extracellular matrix of ruptured ligaments. They were more frequently found later than 3 days after rupture and were seen also at a distance of 2-3 cm from the rupture zone. The presence of dysplastic fibrils may explain the functional insufficiency of the repair tissue in ruptured cruciate ligaments.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-10-01 | Acta Orthopaedica Scandinavica |