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RESEARCH PRODUCT
Arterial Stiffness and Its Relationship to Cardiorespiratory Fitness in Children and Young Adults with a Fontan Circulation
Tim TakkenLaurien C. M. NoortmanEero A. HaapalaEero A. Haapalasubject
MaleYouthsynnynnäiset sydänviatAugmentation Index030204 cardiovascular system & hematologyFontan Procedureaugmentation indexPediatricsuniventricular heart0302 clinical medicinenuoretFontan circulationChildAorta/physiopathologyPulse wave velocityAortaCardiorespiratory Fitness/physiologyHeart Defectseducation.field_of_studycardiorespiratory fitnessExercise Test/methodsVO2 maxMiddle AgedPerinatologyArterial stiffnessand Child HealthCongenital/physiopathologyfyysinen kuntoarterial stiffnessCardiorespiratory FitnessCardiologyOriginal ArticleFemaleCardiology and Cardiovascular MedicineHeart Defects CongenitalAdultmedicine.medical_specialtyAdolescentpulse wave velocityPopulationVascular Stiffness/physiologylapset (ikäryhmät)Pulse Wave AnalysisYoung Adult03 medical and health sciencesVascular StiffnessOscillometry030225 pediatricsInternal medicineJournal ArticlemedicineHumansPediatrics Perinatology and Child Healtheducationnuoret aikuisetbusiness.industryUniventricular heartFontan Procedure/adverse effectsCardiorespiratory fitnessHeart Defects Congenital/physiopathologyAortic Augmentation Indexmedicine.diseaseConfidence intervalPulse wave velocityCross-Sectional StudiesPulse Wave Analysis/methodsPediatrics Perinatology and Child HealthExercise TestArterial stiffnessnuoruusfontan circulationbusinessBody mass indexhuman activitiesdescription
There are no previous studies on arterial stiffness and its associations with cardiorespiratory fitness in young Fontan patients. Therefore, we examined the arterial stiffness and its relationship to cardiorespiratory fitness in children and young adults with a Fontan circulation. Altogether, 17 Fontan patients and 26 healthy controls (16 females and 27 males aged 8–40 years) participated in this cross-sectional study. The cardiorespiratory fitness was assessed by cardiopulmonary exercise testing on a cycle ergometer and was defined as the standard deviation scores (SDS) of peak oxygen uptake per body mass (VO2peak/kg) based on the national reference values and assessed with cardiopulmonary exercise testing on a cycle ergometer. Aortic pulse wave velocity (PWVao) as a measure of arterial stiffness and aortic Augmentation Index (AIX) as a measure of peripheral arterial tone, were assessed by non-invasive oscillometric device from upper arm. Body adiposity was determined by body mass index SDS and the sport participation by interview. Data were analyzed using linear regression analyses and Pearson’s correlations, adjusted for age and sex. Fontan patients had a lower VO2peak/kg-SDS (− 2.69 vs 0.078), higher PWVao-SDS (1.13 vs − 0.24) and higher AIX (19.26% vs 8.49%) in comparison with healthy controls. PWVao and AIX were negatively associated with VO2peak/kg (standard regression coefficient (β) − 0.525, 95% confidence interval (CI) − 0.722 to − 0.227, p < 0.01 and β − 0.371, 95% CI − 0.672 to − 0.080, p = 0.014). Young Fontan patients have the arterial stiffness of healthy people who are twice as old. Thereby, children and young adults with a Fontan circulation have a lower cardiorespiratory fitness and less sport participation. Arterial stiffness is inversely associated with cardiorespiratory fitness and exercise training might be an intervention to improve vascular health in this population. peerReviewed
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2019-04-01 |