6533b7d0fe1ef96bd125ad01

RESEARCH PRODUCT

Glial Protection Against Neuronal Damage

O. KempskiC. Volk

subject

Glutamate uptakeCytosolnervous systemChemistryNeuronal damageIschemiamedicineGlutamate receptorExtracellularNeuronal protectionmedicine.diseaseHomeostasisCell biology

description

Glial homeostatic mechanisms are involved in neuronal protection during the early phase of cerebral ischemia. These protective effects include, among others, glutamate uptake and the regulation of pH in the extracellular space of the brain. Uptake of glutamate goes along with glial swelling, as does the elimination of protons from the glial cytosol. Five transport systems interact in order to maintain a normal intra- and extracellular pH in the brain.

https://doi.org/10.1007/978-3-642-60546-8_18