Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis. A Pilot Study

6533b7d0fe1ef96bd125ad29

RESEARCH PRODUCT

Possible Reduction of Cardiac Risk after Supplementation with Epigallocatechin Gallate and Increase of Ketone Bodies in the Blood in Patients with Multiple Sclerosis. A Pilot Study

Asta Tvarijonaviciute María Mar López-rodríguez Mari-luz Moreno María Benlloch José Enrique De La Rubia Ortí Sandra Carrera-juliá José J. Cerón María Cuerda Ballester Eraci Drehmer Jose Luis Platero Marí ÁNgeles Navarro

subject

Male Pilot Projects Ketone Bodies 030204 cardiovascular system & hematology Epigallocatechin gallate multiple sclerosis Catechin Body Mass Index chemistry.chemical_compound 0302 clinical medicine Functional ability education.field_of_study Nutrition and Dietetics biology 3-Hydroxybutyric Acid Anthropometry food and beverages Middle Aged PON1 C-Reactive Protein Treatment Outcome Cardiovascular Diseases Ketone bodies Female lcsh:Nutrition. Foods and food supply Adult medicine.medical_specialty cardiac risk epigallocatechin gallate Waist Cardiotonic Agents Multiple Sclerosis Population lcsh:TX341-641 Article 03 medical and health sciences Internal medicine medicine Humans education Serum Albumin Analysis of Variance Waist-Height Ratio business.industry Aryldialkylphosphatase Paraoxonase Endocrinology chemistry Heart Disease Risk Factors Dietary Supplements ketone bodies Lean body mass biology.protein business 030217 neurology & neurosurgery Food Science

description

Multiple sclerosis (MS) is a neurodegenerative disease that causes anthropometric changes characterised by functional disability, increase in fat mass, and decrease in lean mass. All these variables are related to a greater cardiac risk. The polyphenol epigallocatechin gallate (EGCG) and an increase in ketone bodies in the blood have been shown to have beneficial effects on anthropometric and biochemical variables related to cardiovascular activity. The aim of this study was to analyse the impact of the intervention with EGCG and ketone bodies on cardiac risk in MS patients. A population of 51 MS patients were randomly assigned to a control group and an intervention group (daily dose of 800 mg of EGCG and 60 mL of coconut oil). Both groups followed an isocaloric diet for 4 months. Levels of beta-hydroxybutyrate (BHB), albumin, paraoxonase 1 (PON1) and C-reactive protein (CRP) were measured in serum before and after the intervention, as well as determining functional ability, waist circumference, waist-to-hip ratio (WHR), waist-to-height ratio (WHtR), fat percentage and muscle percentage. After 4 months, in the intervention group there was a significant increase in BHB, PON1 and albumin, while CRP did not vary

year	journal	country	edition	language
2020-12-10

http://hdl.handle.net/10835/9172