6533b7d0fe1ef96bd125ada3
RESEARCH PRODUCT
Multi-photon imaging of amine-functionalized silica nanoparticles.
Wolfgang TremelFilipe NatalioSusanne StrandAnubha KashyapHannes KerschbaumerDennis StrandHeinz DuschnerMuhammad Nawaz TahirMichael DietzschSteffen Lorenzsubject
chemistry.chemical_classificationPhotoluminescenceMaterials scienceBiocompatibilityCell SurvivalPolymersBiomoleculeDopingNanotechnologySilicon DioxideMetalchemistryMicroscopy FluorescenceQuantum dotvisual_artMicroscopyQuantum Dotsvisual_art.visual_art_mediumHumansNanoparticlesGeneral Materials ScienceAmine gas treatingAminesCells Cultureddescription
A convenient and simple strategy for preparing water soluble, photoluminescent functionalized silica nanoparticles (M-dots) in the absence of fluorophores or metal doping is demonstrated. These M-dots can be used for bioimaging using one and two-photon microscopy. Because of their high photostability, low toxicity and high biocompatibility compared with Lumidot™ CdSe/ZnS quantum dots, functionalized silica particles are superior alternatives for current bioimaging platforms. Moreover, the presence of a free amine group at the surface of the M-dots allows biomolecule conjugation (e.g. with antibodies, proteins) in a single step for converting these photoluminescent SiO(2) nanoparticles into multifunctional efficient vehicles for theragnostics.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2012-06-28 | Nanoscale |