6533b7d0fe1ef96bd125adc9

RESEARCH PRODUCT

Differential Effects of Verapamil on Various Gastric Lesions in Rats

Ricardo BrageBenjamín SarriáMiguel Martí-cabreraJ EspluguesJulio CortijoGuillermo HernandezJuan V. Esplugues

subject

Malemedicine.medical_specialtyGastroenterologyLesionchemistry.chemical_compoundInternal medicinemedicineAnimalsStomach UlcerPharmacologyEthanolDose-Response Relationship Drugbusiness.industryStomachRats Inbred StrainsGeneral MedicineGastric lesionsDifferential effectsRatsEndocrinologymedicine.anatomical_structureVerapamilchemistryGastric MucosaVerapamilFemalemedicine.symptombusinessmedicine.drug

description

Verapamil (3, 10, 20 mg/kg-1) increases the necrotizing effects of oral 25% NaCl or 100% ethanol. Damage by 0.6 N HCl was not equally affected since 1 mg/kg-1 of verapamil decreased the ulcer index whereas the higher doses augmented it. Pharmacologically induced gastric lesions were also differently affected by verapamil, ulcers produced by histamine being greatly enhanced and those of reserpine inhibited. Neither indomethacin nor compound 48/80 ulcers were modified. These results suggest that verapamil modifies the susceptibility of the gastric mucosa to damage.

yearjournalcountryeditionlanguage
1988-01-01Pharmacology
https://doi.org/10.1159/000138348