Towards the elaboration of new gold-based optical theranostics.

6533b7d0fe1ef96bd125add7

RESEARCH PRODUCT

Towards the elaboration of new gold-based optical theranostics.

Richard A. Decréau Christine Goze Laurence Dubrez Laurence Dubrez Ali Bettaieb Ewen Bodio Victor Goncalves Pierre Le Gendre Franck Denat Pierre-emmanuel Doulain Catherine Paul Cindy Racoeur

subject

Boron Compounds Chemistry Optical Imaging Nanotechnology Biological Transport Fluorescence Inorganic Chemistry Normal cell Microscopy Fluorescence Cell Line Tumor Biophysics Organometallic Compounds Humans Bombesin Gold Cancer cell lines Cytotoxicity

description

Four new red BODIPY–gold(I) theranostic compounds were synthesized. Some of them were vectorized by tethering a biovector (glucose or bombesin derivatives) to the metallic center. Their photophysical properties were studied. Additionally, their cytotoxicity was examined on different cancer cell lines and on a normal cell line, they were tracked in vitro by fluorescence detection, and their uptake was evaluated by ICP-MS measurements.

year	journal	country	edition	language
2014-12-11	Dalton transactions (Cambridge, England : 2003)

10.1039/c4dt02977a https://pubmed.ncbi.nlm.nih.gov/25492395

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