Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study

6533b7d0fe1ef96bd125ade8

RESEARCH PRODUCT

Metabolic syndrome and severity of fibrosis in nonalcoholic fatty liver disease: An age-dependent risk profiling study

Elisabetta Bugianesi Luca Valenti Calogero Cammà Mohammed Eslam Silvia Fargion Chiara Rosso Marco Barbara Salvatore Petta Jacob George Antonio Craxì Marianna Porzio

subject

Liver Cirrhosis Male Gastroenterology Body Mass Index 0302 clinical medicine Fibrosis Non-alcoholic Fatty Liver Disease Risk Factors Nonalcoholic fatty liver disease 10. No inequality Diabetes Age Factors Middle Aged Metabolic syndrome 3. Good health Italy Liver 030220 oncology & carcinogenesis Obesity Abdominal 030211 gastroenterology & hepatology Female Waist Circumference Lipoproteins HDL Adult medicine.medical_specialty Diabetes Complications 03 medical and health sciences Diabetes mellitus Internal medicine medicine Humans Nonalcoholic fatty liver disease Obesity Aged Diabetes; Metabolic syndrome; Nonalcoholic fatty liver disease; Obesity; Hepatology Hepatology business.industry nutritional and metabolic diseases Hepatology medicine.disease Obesity Middle age Cross-Sectional Studies Logistic Models diabete Multivariate Analysis Metabolic syndrome Insulin Resistance Hepatic fibrosis business

description

Background & Aims: Metabolic syndrome (MS) and its individual components are associated with the severity and progression of nonalcoholic fatty liver disease (NAFLD). We sought to evaluate the relationship between MS components and the risk of severe hepatic fibrosis in NAFLD patients discriminated by age. Methods: We considered 863 consecutive patients with biopsy-proven NAFLD, who had been fully evaluated for components of MS. Results: Multivariate logistic regression analysis showed that F3-F4 was associated with visceral obesity, IFG/diabetes, and low high-density lipoprotein (HDL) cholesterol, but not triglycerides >150 or arterial hypertension. A significant interaction was found between age and visceral obesity (P=.04). By stratifying patients for age, we confirmed the interaction between inclusion in the third age tertile (>54Â years) and visceral obesity (P=.04). In the lower (54Â years), obesity did not affect the severity of fibrosis, and the risk of severe fibrosis was higher in those with low HDL and IFG/diabetes with/without visceral obesity (52%-54%). Conclusions: Among patients with NAFLD, the metabolic profiles associated with risk for severe fibrosis varied among age groups. Low HDL, obesity and IFG/diabetes were prevalent among patients in the lower and middle age tertiles. HDL and IFG/diabetes but not visceral obesity were prevalent among those in the highest age tertile.

year	journal	country	edition	language
2017-01-01

10.1111/liv.13397 http://hdl.handle.net/2318/1634662