6533b7d0fe1ef96bd125ae3c
RESEARCH PRODUCT
Evidence-based medicine and the problem of healthy volunteers
Giulio MarchesiniSalvatore PettaFrancesca Marchignolisubject
medicine.medical_specialtyLiver EnzymesSpecialties of internal medicinePredictive Value of TestDiseaseGastroenterology03 medical and health sciences0302 clinical medicineClinical trialsLiver Function TestsPredictive Value of TestsReference ValuesNon-alcoholic Fatty Liver DiseaseLiver enzymeInternal medicineNAFLDHealthy volunteersNonalcoholic fatty liver diseasemedicineHumansReference ValueObesitySelection (genetic algorithm)Evidence-Based MedicineHepatologybusiness.industryLiver Function TestPatient SelectionLiver enzymeControl groupGeneral MedicineEvidence-based medicineClinical trials. Control group. Liver Enzymes. NAFLD. Obesitymedicine.diseaseObesityHealthy VolunteerHealthy VolunteersClinical trialClinical trialRC581-951030211 gastroenterology & hepatologybusiness030217 neurology & neurosurgeryHumandescription
Abstract Healthy controls are subjects without the disease being studied but may have other conditions indirectly affecting outcome. In the present epidemics of obesity a few subjects with undiagnosed nonalcoholic fatty liver disease enter clinical studies as controls, producing biased results. Stricter selection criteria should be considered to prevent this risk.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-11-01 |