6533b7d0fe1ef96bd125aec2
RESEARCH PRODUCT
Increased activities of prolyl 4-hydroxylase and galactosylhydroxylysyl glucosyltransferase, enzymes of collagen biosynthesis, in skeletal muscle of endurance-trained mice.
Timo TakalaHenrik AnttinenRaili MyllyläA. SalminenVeikko Vihkosubject
Malemedicine.medical_specialtyTime FactorsPhysiologyClinical BiochemistryProcollagen-Proline DioxygenaseBiologyHydroxyprolinechemistry.chemical_compoundMiceEndurance trainingPhysiology (medical)Internal medicinePhysical Conditioning AnimalmedicineAnimalsReceptorchemistry.chemical_classificationMusclesSkeletal muscleMolecular medicineQuadriceps femoris muscleHindlimbGalactosylhydroxylysyl glucosyltransferaseHydroxyprolinemedicine.anatomical_structureEnzymeEndocrinologychemistryGlucosyltransferasesdescription
The activities of prolyl 4-hydroxylase (PH) and galactosylhydroxylysyl glucosyltransferase (GGT), and the concentration of 4-hydroxyproline were measured in red and white parts of quadriceps femoris muscle of mice after 3, 10, and 20 sessions of daily endurance training. The activities of PH and GGT increased in the red part of the muscle after training for 3 and 10 times and returned to the control level after 20 training sessions. In the white muscle the increase of PH activity was less than in the red muscle. No alteration in GGT activity was observed in the white muscle. The concentration of hydroxyproline was unchanged in the both types of skeletal muscle. The results suggest that collagen turnover in leg muscles may be enhanced during the early phase of adaptation to endurance training. The enhancement is more prominent in red than in white skeletal muscle.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1983-12-01 | Pflugers Archiv : European journal of physiology |