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RESEARCH PRODUCT
Serotonergic polymorphisms in patients suffering from alcoholism, anxiety disorders and narcolepsy.
Christoph FehrAlexandra SchleicherI. O. N. AnghelescuArmin SzegediChristoph KlaweChristoph HiemkeNorbert Dahmensubject
AdultMalemedicine.medical_specialtyGeneralized anxiety disorderGenotypeNeurological disorderTryptophan HydroxylasePolymerase Chain ReactionInternal medicinemedicineHumansReceptor Serotonin 5-HT2ABiological PsychiatryPsychiatric geneticsAllelesNarcolepsyPharmacologySleep disorderPolymorphism GeneticPanic disorderAlcohol dependenceMiddle Agedmedicine.diseaseAnxiety DisordersAlcoholismEndocrinologyReceptors SerotoninAnxietyFemalemedicine.symptomPsychologyNarcolepsydescription
Abstract 1. Alterations in the serotonergic neurotransmission have been frequently described for patients suffering from alcoholism, anxiety disorders and narcolepsy. 2. The authors tested for association of the 5-HT2A receptor polymorphism (T102C) and the intron 7 tryptophan hydroxylase (TPH) polymorphism (A218C) among 176 alcohol dependent patients, 35 patients with panic disorder, 50 patients with generalized anxiety disorder, 55 patients with narcolepsy and 87 healthy controls. 3. Allele and genotype frequencies of the 5-HT2A receptor polymorphism (T102C), the intron 7 TPH polymorphism (A218C) were almost similar between the patients suffering from alcohol dependence, panic disorder, generalized anxiety disorder and narcolepsy 4. There was no association between the 5-HT2A receptor polymorphism (T102C), the intron 7 TPH (A218C) polymorphisms and alcohol dependence, panic disorder, generalized anxiety disorder and narcolepsy in our subsets of German patients.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2001-07-11 | Progress in neuro-psychopharmacologybiological psychiatry |