6533b7d0fe1ef96bd125aefc
RESEARCH PRODUCT
B-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma
Leila MohammadnezhadMojtaba Shekarkar AzgomiMarco Pio La MannaGiuliana GugginoCirino BottaFrancesco DieliNadia Caccamosubject
non-hodgkins lymphomaprimary Sjogren syndrome; non-hodgkins lymphoma; DLBCL; cell signaling; BCROrganic ChemistryGeneral MedicineBCRprimary Sjogren syndromeCatalysisComputer Science ApplicationsInorganic ChemistryDLBCLcell signalingPhysical and Theoretical ChemistryMolecular BiologySpectroscopydescription
Primary Sjogren syndrome (pSS) is the second most common autoimmune disorder worldwide, which, in the worst scenario, progresses to Non-Hodgkin Lymphoma (NHL). Despite extensive studies, there is still a lack of knowledge about developing pSS for NHL. This study focused on cells’ signaling in pSS progression to the NHL type of diffuse large B-cell lymphoma (DLBCL). Using bulk RNA and single cell analysis, we found five novel pathologic-independent clusters in DLBCL based on cells’ signaling. B-cell receptor (BCR) signaling was identified as the only enriched signal in DLBCL and pSS peripheral naive B-cells or salivary gland-infiltrated cells. The evaluation of the genes in association with BCR has revealed that targeting CD79A, CD79B, and LAMTOR4 as the shared genes can provide novel biomarkers for pSS progression into lymphoma.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2023-05-07 | International Journal of Molecular Sciences; Volume 24; Issue 9; Pages: 8385 |