6533b7d0fe1ef96bd125af04

RESEARCH PRODUCT

Evidence against linkage of schizophrenia to chromosome 5q11-q13 markers in systematically ascertained families.

D.b. WildenauerMartha A. ErtlJoachim HallmayerJtirgen MingesSabine SchmidtWolfgang MaierManfred AckenheilDirk Lichtermann

subject

Linkage (software)GeneticsGenetic Markerscongenital hereditary and neonatal diseases and abnormalitiesGenetic LinkageResearch Diagnostic CriteriaPedigree chartmedicine.diseaseFamily memberChromosome (genetic algorithm)Psychotic DisordersSchizophreniamedicineSchizophreniaChromosomes Human Pair 5HumansFamilyLymphocytesLod ScorePsychologyBiological PsychiatryLod scoresLod score

description

Ten pedigrees systematically ascertained in Germany were tested for linkage to chromosome 5q11-q13. In order to replicate the previous report by Sherrington et al (1988), families with a bipolar family member were omitted from the lod score calculations, all diagnoses were based upon Research Diagnostic Criteria, and four different models of the affection status were calculated, including the model for which Sherrington et al calculated the highest lod scores. None of the families investigated showed a positive lod score. Using multipoint linkage analyses, we were able to exclude the region for which a positive linkage has been reported.

yearjournalcountryeditionlanguage
1992-01-01Biological psychiatry
10.1016/0006-3223(92)90008-nhttps://pubmed.ncbi.nlm.nih.gov/1543800