6533b7d0fe1ef96bd125af43

RESEARCH PRODUCT

Synovial giant cells in rheumatoid arthritis: Expression of cystatin C, but not of cathepsin B

Keyszer GmA. GaumannRolf BräuerJörg KriegsmannPeter K. PetrowTorsten Hansen

subject

inorganic chemicalsPathologymedicine.medical_specialtyArthritisCysteine Proteinase InhibitorsToxicologyGiant CellsCathepsin BCathepsin BPathology and Forensic MedicineArthritis RheumatoidOsteoclastCathepsin L1Synovial FluidmedicineHumansCystatin CCathepsinHyperplasiabiologyCell BiologyGeneral Medicinemedicine.diseaseCystatinsImmunohistochemistryMolecular biologymedicine.anatomical_structureCystatin Ccardiovascular systembiology.proteinCystatinSynovial membrane

description

This study was designed to investigate the expression of the matrix degrading proteinase cathepsin B and its endogenous inhibitor cystatin C in rheumatoid arthritis (RA) with special regard to multinucleated synovial giant cells (SGC). We applied an immunohistochemical double-labeling technique. SGC strongly expressed cystatin C and CD68, but were negative for cathepsin B. This staining pattern occurred in osteoclasts as well. Our findings support the idea that in RA matrix destruction by cathepsin B is not mediated by SGC or osteoclasts, but by mononuclear synoviocytes.

yearjournalcountryeditionlanguage
2000-09-15Experimental and Toxicologic Pathology
https://doi.org/10.1016/s0940-2993(00)80055-x