Hematopoietic stem cell quiescence and function are controlled by the CYLD–TRAF2

6533b7d0fe1ef96bd125af53

RESEARCH PRODUCT

Hematopoietic stem cell quiescence and function are controlled by the CYLD–TRAF2–p38MAPK pathway

Yilang Tang Massimo Saini Ari Waisman Melania Tesio Elizabeth Macintyre Andreas Trumpp Lisa Von Paleske Katja Müdder Manolis Pasparakis

subject

TRAF2 Tumor suppressor gene MAP Kinase Signaling System Immunology Regulator Biology p38 Mitogen-Activated Protein Kinases Article Mice medicine Animals Immunology and Allergy Mice Knockout Regulation of gene expression NF-kappa B Hematopoietic stem cell Cell Biology Hematopoietic Stem Cells TNF Receptor-Associated Factor 2 Phenotype Deubiquitinating Enzyme CYLD Cell biology Cysteine Endopeptidases Haematopoiesis medicine.anatomical_structure Gene Expression Regulation Mutation Stem cell

description

Tesio at al. identify a novel pathway controlled by the tumor suppressor and deubiquitinase cylindromatosis (CYLD), which is involved in the regulation of hematopoietic stem cell quiescence and repopulation potential.

year	journal	country	edition	language
2015-04-13	Journal of Experimental Medicine

https://doi.org/10.1084/jem.20141438

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