6533b7d0fe1ef96bd125afa4

RESEARCH PRODUCT

Amplifying effect of serotonin on contractile responses in rat aorta and depletion of intracellular Ca-stores

M P D'ocónM.a. Noguera

subject

MaleSerotoninmedicine.medical_specialtychemistry.chemical_elementAorta ThoracicIn Vitro TechniquesCalciumBiologyMuscle Smooth VascularNorepinephrine (medication)NorepinephrineInternal medicinemedicine.arterymedicineExtracellularAnimalsMagnesiumRats WistarPharmacologyCalcium metabolismAortaAcetylcholineRatsEndocrinologychemistryCatecholamineCalciumSerotoninmedicine.symptomMuscle Contractionmedicine.drugMuscle contraction

description

1. Serotonin, 1 microM, induces a contractile response in isolated rat aorta in the presence or absence of extracellular Ca. 2. In Ca-free media, the fast phasic contraction is lower in magnitude and further addition of serotonin evokes no response. 3. Recovery of the contractile response in Ca-free medium is obtained by a 40 min incubation in Ca-containing solution. 4. In Ca, Mg-free medium, the response to serotonin is significantly higher than that obtained in the presence of Mg. 5. An amplifying effect of serotonin on the contractile responses induced by serotonin itself or by noradrenaline was observed in Ca-containing but not in Ca-free solution.

yearjournalcountryeditionlanguage
1993-05-01General Pharmacology: The Vascular System
https://doi.org/10.1016/0306-3623(93)90220-r