6533b7d0fe1ef96bd125b007

RESEARCH PRODUCT

Duodenal perforation as presentation of gastric neuroendocrine tumour: A case report

Antonino AgrusaGiuseppe Di BuonoSalvatore BuscemiGiulia BonventreGiuseppe BadalamentiGiorgio Romano

subject

medicine.medical_specialtyPerforation (oil well)Case ReportNeuroendocrine tumorsAsymptomaticGastroenterologyExploratory laparoscopyGastric perforation03 medical and health sciences0302 clinical medicineInternal medicinemedicineMultiple endocrine neoplasiaDuodenal PerforationGastrinomabusiness.industrymedicine.diseasedigestive system diseasesZollinger-Ellison syndrome030220 oncology & carcinogenesisGastric NETEmergency surgery030211 gastroenterology & hepatologySurgerymedicine.symptombusinessCarcinoid syndrome

description

Highlights • Gastric neuroendocrine neoplasms (g-NENs) represent the most frequent digestive NENs and are increasingly recognized thanks to diffusion of upper gastrointestinal endoscopy. • g-NENs can be sporadic or associated with multiple endocrine neoplasia type 1 (MEN-1) and present with a functional Zollinger-Ellison syndrome. • We described a case of a 60 years old Caucasian male came to emergency room with diffuse abdominal pain and leukocytosis on blood tests. • At the level of the pyloric portion we found irregularly thickened walls associated with a small fluid collection and bubbles of free air. On exploratory laparoscopy we found a large perforation (about 5 cm of size) in the first duodenum portion. • Histological examination revealed a gastric NET perforation as a consequence of hypergastrinemia secondary to gastrinoma.

yearjournalcountryeditionlanguage
2020-09-01
10.1016/j.ijscr.2020.09.120http://hdl.handle.net/10447/434402