6533b7d0fe1ef96bd125b54a

RESEARCH PRODUCT

Co-loaded cardanol/triazole-halloysite system: characterization of the supramolecular complex and evaluation of its antiproliferative activity

Carmelo Giuseppe CollettiSerena RielaMarina MassaroRenato NotoPaola PomaS. GuernelliFilippo ParisiStefana MiliotoGiuseppe Lazzara

subject

Halloysite drug carrier triazoleSettore BIO/14 - FarmacologiaSettore CHIM/06 - Chimica OrganicaSettore CHIM/02 - Chimica Fisica

description

Halloysite nanotubes modified with triazolium salts (f-HNT) were found to be promising drug carriers for biological molecules [1 ]. In this work we report data about f-HNT as carrier for cardanol, a molecule with interesting biological activity [2]. The interactio n between cardanol and f- HNT was highlighted by HPLC, FTIR spectroscopy, TGA , water contact angle measurements and SEM investigations. Release of cardanol from the system and cytotoxic e ffect of the complex f- HNT/Card on hepatocarcinoma cell lines were, also, evaluated. The obtained results put forward the use of halloysite as drug c arrier

yearjournalcountryeditionlanguage
2014-01-01
https://iris.unipa.it/handle/10447/101891