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RESEARCH PRODUCT
Cyclobutane Pyrimidine Photodimerization of DNA/RNA Nucleobases in the Triplet State
Luis Serrano-andrésRemedios González-luqueIsrael González-ramírezManuela MerchánTeresa Climentsubject
congenital hereditary and neonatal diseases and abnormalitiesPhysics::Biological PhysicsQuantitative Biology::BiomoleculesPyrimidineStereochemistryPyrimidine dimerUracilPhotochemistryQuantitative Biology::GenomicsNucleobaseThymineCyclobutanechemistry.chemical_compoundIntersystem crossingchemistryGeneral Materials SciencePhysical and Theoretical ChemistryCytosinedescription
The photoinduced formation of cyclobutane pyrimidine dimers in the triplet excited state of the DNA/RNA pyrimidine nucleobases pairs has been studied at the CASPT2 level of theory. A stepwise mechanism through the triplet state of the homodimer is proposed for the pairs of nucleobases cytosine, thymine, and uracil involving a singlet−triplet crossing intermediary structure of biradical character representing the most favorable triplet state conformation of the nucleobases as found in the DNA environment. The efficiency of the mechanism will be modulated by two factors: the effectiveness of the triplet−triplet energy transfer process from a donor photosensitizer molecule, which relates to the relative position of the intermediate in the three acceptor systems, determined here to be lower in energy in the thymine and uracil dimers than in the cytosine pairs, and that of the intersystem crossing process toward the ground state of the photoproduct.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-06-21 | The Journal of Physical Chemistry Letters |