6533b7d0fe1ef96bd125b719
RESEARCH PRODUCT
Synthesis and biological evaluation of structural variants of carbazoquinocin C
Alparslan AygünUlf Pindursubject
Oxidative damagechemistry.chemical_compoundOxalyl chloridechemistryCellular dnaRadicalAlkaloidOrganic ChemistryCarbazoquinocin CCombinatorial chemistryBiological evaluationdescription
Some new structural variants of the alkaloid carbazoquinocin C were synthesized in a few steps with good to excellent yields. The key step comprises a cyclisation reaction of appropriate 2-vinylindoles with oxalyl chloride. The carbazole-3,4-quinones are able to trap oxygen-centred radicals. In some biological/biochemical assays some of these compounds exhibit extraordinary results including inhibition of cyclooxygenase-1 and 5-lipoxygenase in the μM-range. Moreover some of the carbazoquinocin C-variants inhibit significant oxidative damage of cellular DNA in nM-range.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2003-05-01 | Journal of Heterocyclic Chemistry |