0000000000132747

AUTHOR

Alparslan Aygün

showing 2 related works from this author

Synthesis and biological evaluation of structural variants of carbazoquinocin C

2003

Some new structural variants of the alkaloid carbazoquinocin C were synthesized in a few steps with good to excellent yields. The key step comprises a cyclisation reaction of appropriate 2-vinylindoles with oxalyl chloride. The carbazole-3,4-quinones are able to trap oxygen-centred radicals. In some biological/biochemical assays some of these compounds exhibit extraordinary results including inhibition of cyclooxygenase-1 and 5-lipoxygenase in the μM-range. Moreover some of the carbazoquinocin C-variants inhibit significant oxidative damage of cellular DNA in nM-range.

Oxidative damagechemistry.chemical_compoundOxalyl chloridechemistryCellular dnaRadicalAlkaloidOrganic ChemistryCarbazoquinocin CCombinatorial chemistryBiological evaluationJournal of Heterocyclic Chemistry
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Chemistry and biology of new marine alkaloids from the indole and annelated indole series.

2003

Chemistry and biology of marine natural products from the indole and annelated indole series have become an attractive research field for development of new pharmacological lead substances. In the past years some of the isolated natural organic compounds were synthesized by chemists and evaluated with great enthusiasm to find new lead natural compounds against different diseases. In this review the latest results for new compounds including isolation, biological evaluation, synthetic pathways and some retrosynthetic analyses are summarized.

PharmacologyIndole testIndolesChemistryOrganic ChemistryAntineoplastic AgentsMarine BiologyMarine Biology (journal)BiochemistryChemical synthesisBiological FactorsStructure-Activity RelationshipAlkaloidsAnti-Infective AgentsPharmaceutical PreparationsDrug DiscoveryMolecular MedicineOrganic chemistryAnimalsBiological evaluationCurrent medicinal chemistry
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