6533b7d0fe1ef96bd125b7dd

RESEARCH PRODUCT

Fatty Acids Composition of Blood Cell Membranes and Peripheral Inflammation in the PREDIMED Study: A Cross-Sectional Analysis

Jordi Salas-salvadóJordi Salas-salvadóEmilio RosEmilio RosJananee MuralidharanJananee MuralidharanMiguel ÁNgel Martínez-gonzálezMiguel ÁNgel Martínez-gonzálezMontserrat FitóDolores CorellaDolores CorellaMònica BullóMònica BullóAleix Sala-vilaAleix Sala-vilaCristina RazquinCristina RazquinNuria Rosique-estebanNuria Rosique-estebanRamon EstruchRamon EstruchOlga CastañerChristopher PapandreouChristopher Papandreou

subject

Male0301 basic medicinemedicine.medical_specialtyCross-sectional studyÀcids grassoslcsh:TX341-641Inflammation030204 cardiovascular system & hematologyfatty acidsArticleBlood cell03 medical and health sciences0302 clinical medicine:Ciencias de la Salud::Medicina preventiva [Materias Investigacion]Internal medicinemedicineHumansFatty acidsAgedcell membranesAged 80 and overInflammationBlood Cells030109 nutrition & dieteticsNutrition and DieteticsChemistryCell MembraneInterleukinMiddle AgedPredimedPeripheralCell membranesCross-Sectional StudiesMembraneEndocrinologymedicine.anatomical_structureinflammationCase-Control StudiesCytokinesFemaleFatty acid compositionmedicine.symptomlcsh:Nutrition. Foods and food supplyMembranes cel·lularsFood Science

description

There is limited evidence from epidemiological studies for the inflammatory or anti-inflammatory properties of fatty acids in blood cell membranes. Therefore, this study examined associations between baseline (n = 282) and 1-year (n = 143) changes in the levels of fatty acids in blood cell membranes with circulating inflammatory markers in older adults at high cardiovascular risk. The data for this cross-sectional analysis was obtained from a case-control study within the PREDIMED study. Linear regression with elastic net penalty was applied to test associations between measured fatty acids and inflammatory markers. Several fatty acids were associated with interferon-&gamma

https://doi.org/10.3390/nu11030576