Modular one-pot synthesis of tetrasubstituted pyrroles from alpha-(alkylideneamino)nitriles.

6533b7d0fe1ef96bd125b882

RESEARCH PRODUCT

Modular one-pot synthesis of tetrasubstituted pyrroles from alpha-(alkylideneamino)nitriles.

subject

chemistry.chemical_classification Aldehydes Nitrile Organic Chemistry One-pot synthesis Nitroalkane Regioselectivity Alkenes Nitro Compounds Aldehyde Chemical synthesis Cycloaddition chemistry.chemical_compound chemistry Cyclization Nitriles Organic chemistry Pyrroles Pyrrole

description

2,3,4,5-Tetrasubstituted pyrroles have been prepared with high regioselectivity by a formal cycloaddition of alpha-(alkylideneamino)nitriles and nitroolefins followed by elimination of HCN and HNO2. The reaction allows the convergent construction of the pyrrole ring in four steps from a nitroalkane and three aldehydes.

year	journal	country	edition	language
2007-08-22	The Journal of organic chemistry

10.1021/jo070426x https://pubmed.ncbi.nlm.nih.gov/17713947

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