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RESEARCH PRODUCT
Early Vascular Aging in Normotensive Patients With Systemic Lupus Erythematosus
Santina CottoneAngelo FerranteFrancesco D'ignotoMassimiliano MorrealeGiuseppe Mulèsubject
Carotid Artery DiseasesMaleSettore MED/09 - Medicina InternaSLEBlood Pressure030204 cardiovascular system & hematologyEssential hypertensionCarotid Intima-Media Thickness0302 clinical medicineRisk FactorsLupus Erythematosus SystemicUltrasonography Doppler Colorskin and connective tissue diseasesPulse wave velocityAge FactorsBlood Pressure Monitoring AmbulatoryMiddle Agedcardiovascular systemCardiologyFemaleVascular agingAortic stiffnessEssential HypertensionCardiology and Cardiovascular MedicineAdultmedicine.medical_specialtyAmbulatory blood pressurePulse Wave AnalysisRenal Circulation03 medical and health sciencesVascular StiffnessInternal medicinemedicineHumansIn patientSettore MED/14 - Nefrologia030203 arthritis & rheumatologyAccelerated atherosclerosisbusiness.industryAtherosclerosismedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareSettore MED/16 - ReumatologiaCase-Control StudiesSubclinical atherosclerosisAsymptomatic DiseasesVASCULAR DAMAGEAORTIC STIFFFNESSEARLY VASCULAR AGINGVascular Resistancebusinessdescription
Connective tissue diseases, like systemic lupus erythematosus (SLE), are associated with early and accelerated atherosclerosis. Recently, the concept of “early vascular aging” (EVA) has been more widely accepted. Aortic stiffness is one of the important markers of EVA. We evaluated EVA and subclinical atherosclerosis, by measuring aortic pulse wave velocity (aPWV) and carotid intima–media thickness (cIMT), in 50 normotensive patients with SLE (mean age: 39 ± 12 years). We compared these participants with 50 age- and sex-matched patients with essential hypertension (EH) and 20 healthy controls. Each participant underwent 24-hour ambulatory blood pressure monitoring (ABPM), aPWV, and cIMT measurements. Clinic and 24-hour ABPM values were significantly lower in patients with SLE and controls when compared with the participants having EH (all P < .0001), but aPWV and cIMT were significantly lower in the control group when compared with patients having SLE and EH (all P < .001). Overall, patients with SLE and EH had similar cIMT and aPWV values ( P = .31 and P = .47, respectively). Our results suggest that SLE has a similar deleterious impact on EVA as EH.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-11-03 | Angiology |