6533b7d0fe1ef96bd125b9aa

RESEARCH PRODUCT

Computerized brain tomography measures compared with spontaneous and suppressed plasma cortisol levels in major depression.

Ulrich FrommbergerUlrich FrommbergerKlaus WiedemannKlaus WiedemannS. SchlegelFlorian HolsboerFlorian HolsboerUlrich Von BardelebenUlrich Von Bardeleben

subject

AdultMalemedicine.medical_specialtyHydrocortisoneEndocrinology Diabetes and MetabolismDexamethasoneCerebral VentriclesBasal (phylogenetics)EndocrinologyInternal medicineMelancholiaBrief Psychiatric Rating ScalemedicineHumansBiological PsychiatryDexamethasoneDepression (differential diagnoses)HydrocortisonePsychiatric Status Rating ScalesDepressive DisorderEndocrine and Autonomic SystemsBrainMiddle AgedVentricular-brain ratioPsychiatry and Mental healthEndocrinologyDexamethasone suppression testFemalemedicine.symptomPsychologyTomography X-Ray Computedmedicine.drug

description

We determined brain density and ventricular measurements with computerized tomography (CT) in 33 depressed patients and compared the results with basal plasma cortisol and its suppressibility by dexamethasone. Mean plasma cortisol was positively related to elevated ventricular brain ratio (VBR). No association could be found between dexamethasone suppression test (DST) status and VBR or any other CT parameter. Elevated plasma cortisol levels and increased VBRs were positively correlated with total scores on the Brief Psychiatric Rating Scale, the Global Assessment Scale and the Bech-Rafaelsen Melancholia Scale, but they were not significantly correlated with total score on the Hamilton Anxiety Scale.

yearjournalcountryeditionlanguage
1989-01-01Psychoneuroendocrinology
10.1016/0306-4530(89)90019-xhttps://pubmed.ncbi.nlm.nih.gov/2756074