Cardiorespiratory Fitness and Physical Activity following Lung Transplantation: A National Cohort Study

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RESEARCH PRODUCT

Cardiorespiratory Fitness and Physical Activity following Lung Transplantation: A National Cohort Study

May Brit Samersaw-lund May Brit Samersaw-lund Mariann Ulvestad Mariann Ulvestad Bjørge Herman Hansen Elisabeth Edvardsen Michael T. Durheim Michael T. Durheim Johny Kongerud Johny Kongerud

subject

Pulmonary and Respiratory Medicine Adult Male medicine.medical_specialty Cystic Fibrosis medicine.medical_treatment Physical activity National cohort Cohort Studies 03 medical and health sciences Hemoglobins Pulmonary Disease Chronic Obstructive Young Adult 0302 clinical medicine Oxygen Consumption Forced Expiratory Volume medicine Lung transplantation Humans 030212 general & internal medicine License Exercise Aged Exercise Tolerance Cardiovascular Deconditioning business.industry Norway Pulmonary Gas Exchange Cardiorespiratory fitness Cardiopulmonary exercise testing Creative commons Middle Aged VDP::Medisinske Fag: 700::Idrettsmedisinske fag: 850 030228 respiratory system Cardiorespiratory Fitness Family medicine Exercise Test Female business Lung Diseases Interstitial VDP::Samfunnsvitenskap: 200::Samfunnsvitenskapelige idrettsfag: 330 Lung Transplantation

description

Background: Low cardiorespiratory fitness and inactivity are common after lung transplantation (LTx). The causes of exercise intolerance are incompletely understood. Objectives: The aim of this study was to objectively assess cardiorespiratory fitness and physical activity, evaluate causes of exercise intolerance, and explore clinical factors associated with cardiorespiratory fitness after bilateral LTx (BLTx). Materials and Methods: Peak oxygen uptake (V∙O2peak) and exercise-limiting factors were evaluated by a treadmill cardiopulmonary exercise test (CPET) 6–60 months after BLTx. Physical activity was measured with accelerometers, and results were compared with Norwegian normative data and the World Health Organization’s (WHO) recommendations for physical activity. Results: In 54 included BLTx recipients (mean age 50 ± 15 years, 50% females), V∙O2peak (mL × kg–1 × min–1) was 21.8 ± 7.7 for men and 22.4 ± 6.2 for women, corresponding to 57 ± 17 and 70 ± 12% of predicted, respectively. Three patients (6%) met criteria for normal V∙O2peak. Deconditioning limited V∙O2peak in 22 patients (41%), while ventilatory limitation and abnormal gas exchange were observed in 14 (26%) and 20 (37%) patients, respectively (some had more than 1 finding). Forty-three patients (86%) did not meet the WHO physical activity recommendations. There was a moderate correlation between V∙O2peak and physical activity (r = 0.642, p &#x3c; 0.01). Body mass index, physical activity, forced expiratory volume after 1 second, sex, and hemoglobin together accounted for 73% of the variability in V∙O2peak. Conclusions: Low cardiorespiratory fitness was observed in the majority of BLTx recipients. Both deconditioning and cardiopulmonary limitations were common findings. Nearly 90% were classified as being inactive according to physical activity recommendations. CPET appears to identify a deconditioned subgroup of BLTx recipients for whom exercise training may be especially beneficial.

year	journal	country	edition	language
2020-01-13

10.1159/000506883 http://hdl.handle.net/10852/83005