6533b7d1fe1ef96bd125c3a4
RESEARCH PRODUCT
Stereoselective Synthesis of Microcarpalide
Miguel CardaJuan MurgaJ. Alberto MarcoJorge Garcia‐fortanetEva Falomirsubject
Molecular StructureChemistryStereochemistryOrganic ChemistryFungiTotal synthesisStereoisomerismAlcoholGeneral MedicineMetathesisBiochemistryTurn (biochemistry)Heterocyclic Compounds 1-Ringchemistry.chemical_compoundAlkanesStereoselectivityPhysical and Theoretical ChemistryMicrocarpalidedescription
The first total synthesis of the naturally occurring nonenolide, microcarpalide, is described. The key step in the synthesis was the ring-closing metathesis of a dienic ester prepared in turn by coupling an acid and an alcohol stereoselectively synthesized from (S,S)-tartaric acid and (R)-glycidol, respectively. [structure: see text]
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2002-08-30 | Organic Letters |