6533b7d1fe1ef96bd125c3af

RESEARCH PRODUCT

Prevention of 7-Ketocholesterol-Induced Overproduction of Reactive Oxygen Species, Mitochondrial Dysfunction and Cell Death with Major Nutrients (Polyphenols, ω3 and ω9 Unsaturated Fatty Acids) of the Mediterranean Diet on N2a Neuronal Cells

Hélène Greige-gergesLizette AuezovaGérard LizardMohammad SamadiAnne VejuxAline YammineAline YammineThomas NuryNorbert LatruffeDominique Vervandier-fasseur

subject

eicosapentaenoic acidPharmaceutical ScienceResveratrolDiet Mediterraneanmedicine.disease_causequercetinAnalytical ChemistryMicechemistry.chemical_compound0302 clinical medicineDrug Discoveryoxidative stressKetocholesterolsNeuronschemistry.chemical_classification0303 health sciencesCell Deathfood and beveragesdocosahexaenoic acidEicosapentaenoic acidMitochondriaBiochemistryChemistry (miscellaneous)Docosahexaenoic acid030220 oncology & carcinogenesisMolecular Medicineα-linolenic acidN2a cellsArticlelcsh:QD241-44103 medical and health sciencesresveratrol.lcsh:Organic chemistryCell Line TumorMediterranean dietFatty Acids Omega-3medicineAnimalsPropidium iodidePhysical and Theoretical Chemistry7-ketocholesterol030304 developmental biologyapigeninReactive oxygen speciesOrganic ChemistryNeurotoxicityPolyphenolsmedicine.diseaseOleic acidoleic acidchemistryReactive Oxygen SpeciesOxidative stress

description

The brain, which is a cholesterol-rich organ, can be subject to oxidative stress in a variety of pathophysiological conditions, age-related diseases and some rare pathologies. This can lead to the formation of 7-ketocholesterol (7KC), a toxic derivative of cholesterol mainly produced by auto-oxidation. So, preventing the neuronal toxicity of 7KC is an important issue to avoid brain damage. As there are numerous data in favor of the prevention of neurodegeneration by the Mediterranean diet, this study aimed to evaluate the potential of a series of polyphenols (resveratrol, RSV

yearjournalcountryeditionlanguage
2020-05-01Molecules
https://doi.org/10.3390/molecules25102296