6533b7d1fe1ef96bd125c3b9
RESEARCH PRODUCT
Multicomponent solid dispersion a new generation of solid dispersion produced by spray-drying
Bahijja Tolulope Raimi-abrahamLaura Modica De MohacRoberto CaruanaGiammona GaetanoMariano Licciardisubject
chemistry.chemical_classificationMaterials sciencePharmaceutical ScienceExcipient02 engineering and technologyPolymer021001 nanoscience & nanotechnology030226 pharmacology & pharmacyDosage form03 medical and health sciences0302 clinical medicineChemical engineeringchemistrySpray dryingmedicineDissolution testingSolubility0210 nano-technologyDispersion (chemistry)Multicomponent solid dispersion Spray-drying Dissolution rates Dosage form Polymersmedicine.drugdescription
Abstract The term “multicomponent solid dispersion” is widely used in recent literature to describe solid formulations consisting of a special excipient's mixture and active molecules finely dispersed. However, this term has not yet been defined. In this review, we aimed to improve the definition of multicomponent solid dispersions as a new generation of solid dispersions capable to improve both formulation issues and the therapeutic effect of the final dosage form. As it is well-known the use of solid dispersions to improve drug dissolution rate and solubility, this review describes the field of solid dispersions as well as the formulation strategies available for their production. In particular, the review highlights the use of the spray-drying technique and the benefits provided by this method in the manufacturing of multicomponent solid dispersion.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-06-01 | Journal of Drug Delivery Science and Technology |