6533b7d1fe1ef96bd125c418

RESEARCH PRODUCT

Prevalence of herpes simplex, Epstein Barr and human papilloma viruses in oral lichen planus.

Cem DemirBurcu SengüvenBenay Yıldırım

subject

AdultMaleSimplexvirusHerpesvirus 4 Humanfood.ingredientvirusesmedicine.disease_causeVirusYoung Adultfoodstomatognathic systemmedicineHumansSimplexvirusskin and connective tissue diseasesGeneral DentistryPathologicalAgedHuman papillomavirus 16integumentary systembusiness.industryEpstein-Barr Virus PositiveMiddle Agedmedicine.disease:CIENCIAS MÉDICAS [UNESCO]Epstein–Barr virusVirologystomatognathic diseasesHerpes simplex virusCross-Sectional StudiesOtorhinolaryngologyImmunologyUNESCO::CIENCIAS MÉDICASPapillomaSurgeryOral lichen planusFemalebusinessLichen Planus Oral

description

Objectives: The aim of the present study was to assess the prevalence of Herpes Simplex virus, Epstein Barr virus and Human Papilloma virus -16 in oral lichen planus cases and to evaluate whether any clinical variant, histopathological or demographic feature correlates with these viruses. Study Design: The study was conducted on 65 cases. Viruses were detected immunohistochemically. We evaluated the histopathological and demographic features and statistically analysed correlation of these features with Herpes Simplex virus, Epstein Barr virus and Human Papilloma virus-16 positivity. Results: Herpes Simplex virus was positive in six (9%) cases and this was not statistically significant. The number of Epstein Barr virus positive cases was 23 (35%) and it was statistically significant. Human Papilloma virus positivity in 14 cases (21%) was statistically significant. Except basal cell degeneration in Herpes Simplex virus positive cases, we did not observe any significant correlation between virus positivity and demographic or histopathological features. However an increased risk of Epstein Barr virus and Human Papilloma virus infection was noted in oral lichen planus cases. Conclusions: Taking into account the oncogenic potential of both viruses, oral lichen planus cases should be detected for the presence of these viruses

yearjournalcountryeditionlanguage
2011-01-01Medicina oral, patologia oral y cirugia bucal
10.4317/medoral.16.e170https://pubmed.ncbi.nlm.nih.gov/21196875