6533b7d1fe1ef96bd125c4a4

RESEARCH PRODUCT

Possible involvement of the IL4 gene in Waldenström's macroglobulinemia

Fabio CaradonnaG. GranataGiusi BarbataP. Carbone

subject

Cancer Researchmedicine.medical_treatmentGrowth factorWaldenstrom macroglobulinemiaMacroglobulinemiaBiologymedicine.diseaseMalignancyMolecular biologyBlotting SouthernSettore BIO/18 - GeneticaCytokineImmunologyGeneticsmedicinebiology.proteinHumansInterleukin-4Waldenstrom MacroglobulinemiaAntibodyIL-4 gene Waldenstrom's MacroglobulinemiaMolecular BiologyInterleukin 4Southern blot

description

Abstract We report the results of a molecular investigation of 11 patients affected by Waldenstrom's macroglobulinemia, a rare B-cell malignancy characterized by an excessive proliferation of immunoglobulin(Ig)M-secreting plasmacytoid cells. In particular, we studied the interleukin-4 (IL4) gene, which codes for a B-specific growth factor capable of stimulating the proliferation and differentiation of secreting plasma cells. By Southern hybridization, in three patients we found the presence of additional bands in comparison with the expected pattern; moreover, these bands showed a different degree of intensity.

yearjournalcountryeditionlanguage
1994-07-01Cancer Genetics and Cytogenetics
https://doi.org/10.1016/0165-4608(94)90170-8