6533b7d1fe1ef96bd125cb87
RESEARCH PRODUCT
High-Yield Formation of Arbutin from Hydroquinone by Cell-Suspension Cultures ofRauwolfia serpentina
Joachim StöckigtRalf Lutterbachsubject
chemistry.chemical_classificationChromatographyNatural productApocynaceaebiologyHydroquinoneChemistryOrganic ChemistryArbutinGlycosidebiology.organism_classificationBiochemistrySuspension cultureCatalysisInorganic Chemistrychemistry.chemical_compoundBiosynthesisBiochemistryYield (chemistry)Drug DiscoveryPhysical and Theoretical Chemistrydescription
High-density cell-suspension cultures of Rauwolfia serpentina cultivated in a nutrition medium optimized for the production of the glucoalkaloid raucaffricine synthesize hydroquinone glycosides from continuously added hydroquinone with a total yield of 23.87 g/1 (18 g/1 of arbutin and 5.87 g/1 of a hydroquinone diglycoside) in 7 days. This arbutin production is by far the highest formation of a natural product by plant-cell-culture systems reported to date.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1992-10-02 | Helvetica Chimica Acta |