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RESEARCH PRODUCT
13C NMR spectral assignments of 3α,3′α-bis(arylcarboxy)-5β-cholan-24-oic acid ethane-1,2-diol diesters: new lithocholic acid-based molecular clefts
Kari LappalainenHannu SaloKatri LaihiaPia MänttäriJari TamminenErkki Kolehmainensubject
Lithocholic acidMolecular massDiolGeneral ChemistryCarbon-13 NMRMass spectrometryChloridechemistry.chemical_compoundchemistryIonizationDesorptionmedicineOrganic chemistryGeneral Materials Sciencemedicine.drugdescription
3α,3′α-Bis(arylcarboxy)-5β-cholan-24-oic acid ethane-1,2-diol diesters (1–3) were synthesized by the reaction of an aroyl chloride (aroyl=2,6-dichlorobenzoyl, 2-naphthoyl and 1-pyrenoyl) with lithocholic acid (3α-hydroxy-5β-cholan-24-oic acid) ethane-1,2-diol diester. The 13C NMR chemical shift assignments of the formed molecular clefts 1–3, pyrene-1-carboxylic acid methyl ester (4) (used as model compound) and 1-pyrenoyl chloride (5) are based on literature data and 13C DEPT-135, 1H,13C HMQC and 1H,13C HMBC experiments. The molecular weights of 1–3 were determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Copyright © 1999 John Wiley & Sons, Ltd.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-02-01 | Magnetic Resonance in Chemistry |