Zur Aussagekraft humanpharmakologischer Pr�fmethoden f�r den Wirkungsvergleich von Corticoidexterna

6533b7d1fe1ef96bd125cbdf

RESEARCH PRODUCT

Zur Aussagekraft humanpharmakologischer Pr�fmethoden f�r den Wirkungsvergleich von Corticoidexterna

H. Holzmann H. Lachner

subject

Gynecology medicine.medical_specialty business.industry Value (economics)medicine Dermatology General Medicine business

description

Zur Abklarung grundsatzlicher methodologischer Fragen bei humanpharmakologischen Vergleichsprufungen haben wir den reaktionspraventiven Effekt von vier charakteristischen externcorticoiden (1. Hydrocortison, 2. Betamethasen, 3. Fluocinolon und 4. Flumethason) an vier artifiziellen Entzundungsmodellen (1. Rubefacienstest, 2. Histamin-Dermatitis, 3. UV-Dermatitis und 4. Epidermaler Allergen-Kontakttest) der menschlichen Haut studiert. Die gleichzeitige Benutzung mehrerer Entzundungsmodelle erwies sich dabei fur die pharmakologische Charakterisierung von Corticoidexterna als sehr nutzlich, da sich verschiedene Corticoide den differenten Pathomechanismen entzundlicher Hautprozesse gegenuber recht unterschiedlich verhalten.

year	journal	country	edition	language
1969-01-01	Archiv f�r Klinische und Experimentelle Dermatologie

https://doi.org/10.1007/bf00499536

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