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RESEARCH PRODUCT

Saponins from the Roots of Nylandtia spinosa

Jean François MirjoletCheikh DiomeAnne Claire Mitaine-offerTomofumi MiyamotoClément DelaudeMarie Aleth Lacaille-duboisOlivier Duchamp

subject

Nylandtia spinosaCoumaric AcidsSpermidineStereochemistrySaponinPharmaceutical SciencePharmacognosyPlant RootsAnalytical ChemistryInhibitory Concentration 50TriterpeneDrug DiscoveryHumansNuclear Magnetic Resonance BiomolecularPharmacologychemistry.chemical_classificationPlants MedicinalMolecular StructureChemistryOrganic ChemistryGlycosideTenuifolinSaponinsTriterpenesTerpenoidPolygalaceaeHuman colon cancerComplementary and alternative medicineMolecular MedicineDrug Screening Assays Antitumor

description

From the roots of Nylandtia spinosa, four new triterpene saponins, 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-galactopyranosyl-(1-->4)-[alpha- l-arabinopyranosyl-(1-->3)]-beta- d-xylopyranosyl-(1-->4)-[beta- d-apiofuranosyl-(1-->3)]-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester ( 1), 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-galactopyranosyl-(1-->4)-[alpha- l-arabinopyranosyl-(1-->3)]-beta- d-xylopyranosyl-(1-->4)-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester ( 2), 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-apiofuranosyl-(1-->4)-[beta- d-galactopyranosyl-(1-->2)]-beta- d-xylopyranosyl-(1-->4)-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester ( 3), and 3- O-beta- d-glucopyranosylpresenegenin 28- O-beta- d-apiofuranosyl-(1-->3)-beta- d-xylopyranosyl-(1-->4)-alpha- l-rhamnopyranosyl-(1-->2)-beta- d-fucopyranosyl ester ( 4), were isolated, together with the known tenuifolin. Their structures were established mainly by 2D NMR techniques and mass spectrometry. Compounds 1- 4 were evaluated for cytotoxicity against HCT 116 and HT-29 human colon cancer cells, but were inactive (IC50 > 5 microg/mL).

yearjournalcountryeditionlanguage
2007-10-12Journal of Natural Products
https://doi.org/10.1021/np0703186