6533b7d1fe1ef96bd125ccfe
RESEARCH PRODUCT
Hyperpigmentation of hard palate induced by chloroquine therapy
Edgar-manuel Muñoz-camposRicardo Martinez-pedrazaBruno-augusto-benevenuto De AndradeNelson-alejandro Padron-alvaradoThayná-melo-de Lima Moraissubject
medicine.medical_specialtyMedication historyCase Report03 medical and health sciences0302 clinical medicineChloroquinemedicineAntimalarial AgentOral mucosaAdverse effectGeneral DentistryOral Medicine and Pathologybusiness.industry030206 dentistrymedicine.disease:CIENCIAS MÉDICAS [UNESCO]HyperpigmentationDermatologymedicine.anatomical_structure030220 oncology & carcinogenesisRheumatoid arthritisUNESCO::CIENCIAS MÉDICASHard palatemedicine.symptombusinessmedicine.drugdescription
The antimalarials are one of the most commonly prescribed drugs for conditions such as lupus erythematosus and rheumatoid arthritis, and the side effects, though infrequent, are well known. The antimalarial agent chloroquine diphosphate usually causes pigmentary changes in the oral mucosa characterized by a bluish-grey to black discolorations mainly in the hard palate. Considering only the hard palate hyperpigmentation caused by chloroquine, to the best of our knowledge, only 13 cases have been reported in the English language literature. We described an additional case of palate hyperpigmentation related to the chronic use of chloroquine diphosphate in a 60-year-old Mexican woman. Although the diagnosis is usually made based on medication history and clinical presentation, a biopsy specimen may be helpful to confirm the diagnosis. Clinicians must be aware of these drugs and their adverse effects in order to make the correct diagnosis and decide on the optimal treatment for the condition. Key words:Oral cavity, hard palate, hyperpigmentation, chloroquine, antimalarials.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-12-01 |