6533b7d1fe1ef96bd125cdf6

RESEARCH PRODUCT

Urinary Tartaric Acid, a Biomarker of Wine Intake, Correlates with Lower Total and LDL Cholesterol.

José LapetraAnna Tresserra-rimbauAnna Tresserra-rimbauEmilio RosMiquel FiolRamon EstruchRamon EstruchMiguel ÁNgel Martínez-gonzálezIsabella Parilli-moserIsabella Parilli-moserCamila Arancibia-riverosInés Domínguez-lópezCarolina Ortega-azorínCarolina Ortega-azorínLuis Serra-majemLluis Serra-majemXavier PintóEnrique Gómez-graciaEnrique Gómez-graciaRosa M. Lamuela-raventósRosa M. Lamuela-raventósFernando ArósJordi Salas-salvadóOlga Castañer

subject

Mediterranean dietmenopauseWineUrinechemistry.chemical_compoundTX341-641TartratesRandomized Controlled Trials as TopicAged 80 and overNutrition and Dieteticsmedicine.diagnostic_testAnthropometryMiddle Agedlipid profilebody fatCholesterolCardiovascular DiseasesFemaleMenopausaPREDIMEDcardiovascular riskmedicine.medical_specialtyWaistAlcohol DrinkingÀcid tàrtricArticleInternal medicineMediterranean dietmedicineHumanspolyphenolsAgedWinebusiness.industryCholesterolMalalties cardiovascularsNutrition. Foods and food supplybiomarkersmediterranean dietCholesterol LDLEndocrinologyCross-Sectional StudieschemistryHeart Disease Risk Factorstartaric acidLipid profilebusinessBody mass indexFood ScienceLipoprotein

description

Postmenopausal women are at higher risk of developing cardiovascular diseases due to changes in lipid profile and body fat, among others. The aim of this study was to evaluate the association of urinary tartaric acid, a biomarker of wine consumption, with anthropometric (weight, waist circumference, body mass index (BMI), and waist-to-height ratio), blood pressure, and biochemical variables (blood glucose and lipid profile) that may be affected during the menopausal transition. This sub-study of the PREDIMED (Prevención con Dieta Mediterránea) trial included a sample of 230 women aged 60–80 years with high cardiovascular risk at baseline. Urine samples were diluted and filtered, and tartaric acid was analyzed by liquid chromatography coupled to electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). Correlations between tartaric acid and the study variables were adjusted for age, education level, smoking status, physical activity, BMI, cholesterol-lowering, antihypertensive, and insulin treatment, total energy intake, and consumption of fruits, vegetables, and raisins. A strong association was observed between wine consumption and urinary tartaric acid (0.01 μg/mg (95% confidence interval (CI): 0.01, 0.01), p-value &lt

yearjournalcountryeditionlanguage
2021-08-22Nutrients
10.3390/nu13082883https://pubmed.ncbi.nlm.nih.gov/34445043