6533b7d1fe1ef96bd125ce9c

RESEARCH PRODUCT

On-line sample treatment and FT-IR determination of doxylamine succinate in pharmaceuticals

Miguel De La GuardiaJosep F. Ventura-gayeteSalvador Garrigues

subject

SolventAnalyteChromatographyDoxylamineChemistryStandard additionmedicineSample preparationDoxylamine SuccinateFourier transform infrared spectroscopyFourier transform spectroscopyAnalytical Chemistrymedicine.drug

description

Abstract A low solvent consumption method for Fourier transform infrared spectroscopy (FT-IR) determination of doxylamine succinate in pharmaceuticals has been developed. The analyte was continuous and selectively extracted with a 13% (v/v) ethanol:chloroform solvent mixture, recirculating the solvent through the sample and monitoring the process by FT-IR. Doxylamine succinate was determined by on-line standard addition measuring the peak area in the regions 1730–1710 and 1485–1462 cm −1 corrected with a two-point baseline established between 2000 and 1800 cm −1 . This new method implies low volumes of chloroformic solvent mixture, only 2.6 mL per sample, in front of classical batch FT-IR methods, improving analytical efficiency and reducing waste generation. The on-line extraction and standard addition determination of doxylamine succinate allowed a throughput of 10 h −1 .

yearjournalcountryeditionlanguage
2005-10-25Talanta
https://doi.org/10.1016/j.talanta.2006.02.023