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RESEARCH PRODUCT
Distinct Xp11.2 breakpoints in two renal cell carcinomas exhibiting X;autosome translocations
E. Van Den BergM.j.m. WilbrinkA.j.m. BraamR.p. FolkersA. Geurts Van KesselMarian A. J. WetermanB. De JongStephan StörkelTrijnie Dijkhuizensubject
MaleCancer Researchmedicine.medical_specialtycongenital hereditary and neonatal diseases and abnormalitiesX ChromosomeChromosomal translocationBiologyTranslocation GeneticCLASSIFICATIONCHILDGeneticsmedicineCarcinomaHumansDe rol van chromosoomafwijkingen en (anti-)oncogenen in humane tumorenCarcinoma Renal CellGeneralLiterature_REFERENCE(e.g.dictionariesencyclopediasglossaries)In Situ Hybridization FluorescenceX chromosomeAgedGeneticsAutosomeBreakpointCytogeneticsKaryotypeADENOCARCINOMAMiddle Agedmedicine.diseaseMolecular biologyTUMORSCYTOGENETICSKidney NeoplasmsChromosome BandingAdenocarcinomaThe role of chromosomal aberrations and (anti-)oncogenes in human tumoursdescription
Several human renal cell carcinomas with X;autosome translocations have been reported in recent years. The t(X; I)(p11.2;q21) appears to be a specific primary anomaly, suggesting that tumors with this translocation form a distinct subgroup of RCC. Here we report two new cases, one with a t(X;10)(p11.2;q23), the other with a t(X;1)(p11.2;p34). The common breakpoint in Xp11.2 suggests that they belong to the above-mentioned subset of RCC. Using FISH in conjunction with X-specific YAC clones, we demonstrate that the two new cases exhibited distinct breakpoints within Xp11.2. (C) 1995 Wiley-Liss, Inc.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-09-01 | Genes, chromosomes & cancer |