6533b7d1fe1ef96bd125d796
RESEARCH PRODUCT
Multi or Single-Kinase Inhibitors to Counteract Drug Resistance in Cancer: What is New?
Patrizia DianaCamilla PecoraroDaniela CarboneStella Maria CascioferroBarbara Parrinosubject
PharmacologySmall molecules kinase inhibitorspolypharmacologycovalent kinase inhibitorsallosteric inhibitorsDrug DiscoveryOrganic ChemistryMolecular Medicineanticancer drug combinationsBiochemistrykinase genetic aberrationSettore CHIM/08 - Chimica Farmaceuticadescription
The concept of protein kinase inhibition starts from the groundbreaking research on the role of these proteins in the regulation of fundamental processes, including proliferation, cell cycle, apoptosis, metabolism, and inflammation. Kinase genetic mutations, as well as overexpression and dysregulation, can contribute to the development of several diseases, including neoplasms, leading to relapses and resistance to standard drug chemotherapy [1-3].
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2023-02-01 |