6533b7d1fe1ef96bd125d8ea

RESEARCH PRODUCT

Interpositus nucleus inactivation reduces unconditioned response amplitude after paired but not explicitly unpaired treatment in rabbit eyeblink conditioning.

Tapani KorhonenJan Wikgren

subject

CerebellumBlinkingChemistryGeneral NeuroscienceConditioning ClassicalClassical conditioningUnconditioned responseUnconditioned stimulusConditioning EyelidCold TemperatureAmplitudemedicine.anatomical_structureEyeblink conditioningCerebellar NucleiBiophysicsmedicineReflexAnimalsRabbitsNeuroscienceNucleus

description

The amplitude of unconditioned responses (URs) in unconditioned stimulus (US) alone presentations were measured in six rabbits during explicitly unpaired and classical conditioning treatments. After both phases of the experiment, the interpositus nucleus (IPN) was reversibly inactivated by a cold probe. URs after unpaired treatment were unaffected by inactivation but after acquisition of a robust level of conditioned responses (CRs), URs in US-alone test trials were reduced in amplitude compared with URs immediately before and after inactivation. The results suggest that the IPN has a role in CR-related reflex modification.

yearjournalcountryeditionlanguage
2001-08-02Neuroscience letters
10.1016/s0304-3940(01)02000-6https://pubmed.ncbi.nlm.nih.gov/11479018