6533b7d1fe1ef96bd125d96d
RESEARCH PRODUCT
Determination of acetylcholine, nitrostigmine and acetylcholinesterase activity in four patients with severe nitrostigmine (E 605 forte) intoxication.
S. OkonekH. Kilbingersubject
AdultMaleInsecticidesErythrocytesAdolescentHealth Toxicology and MutagenesisPoison controlAdipose tissueAdministration OralPharmacologyToxicologychemistry.chemical_compoundCerebrospinal fluidOrganophosphorus CompoundsBlood plasmaMedicineIngestionHumansbusiness.industryPoisoningClinical courseGeneral MedicineMiddle AgedNitro CompoundsAcetylcholinesteraseAcetylcholineSuicidechemistryAdipose TissueIntestinal AbsorptionAcute DiseaseAcetylcholinesteraseFemalebusinessAcetylcholinemedicine.drugdescription
Concentrations of acetylcholine and nitrostigmine as well as acetylcholinesterase activity were determined in 4 patients with severe nitrostigmine intoxication. In the acute phase of the intoxication, acetylcholine levels up to 36 and 55 ng/ml were found in blood plasma and cerebrospinal fluid, respectively. At the same time no activity of acetylcholinesterase in plasma and erythrocytes was detected. Acetylcholinesterase activity gradually recovered at the end of the second week. In the first 3 days after the ingestion plasma nitrostigmine concentrations ranged from 409 to 86 ng/ml. At the end of the third week nitrostigmine was still found in a concentration of about 1 ng/ml plasma. Redistribution from fatty tissue and slow gastro-intestinal absorption may be responsible for the persistence of nitrostigmine in the blood. The findings are discussed in relation to the clinical course.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1974-01-01 | Archives of toxicology |