6533b7d2fe1ef96bd125e0f3
RESEARCH PRODUCT
The Neuroepithelium Disruption Could Generate Autoantibodies against AQP4 and Cause Neuromyelitis Optica and Hydrocephalus
Emilia M. Carmona-caleroAgustín Castañeyra-perdomoMaría Castañeyra-ruizJuan M. González-toledoAgustín Castañeyra-ruizFrancisco J. Perez-moltoLeandro Castañeyra-ruizIbrahim González-marrerosubject
Pathologymedicine.medical_specialtyNeuromyelitis opticabusiness.industryurogenital systemNeuritisMyelitisReview Articlemedicine.diseasePathophysiologyeye diseasesHydrocephalusNeuroepithelial cellCerebrospinal fluidmedicineOptic nervebusinessdescription
Neuromyelitis optica is an inflammatory disease characterized by neuritis and myelitis of the optic nerve. Its physiopathology is connected with the aquaporin-4 water channel, since antibodies against aquaporin-4 have been found in the cerebrospinal fluid and blood of neuromyelitis optica patients. The seropositivity for aquaporin-4 antibodies is used for the diagnosis of neuromyelitis optica or neuromyelitis optica spectrum disease. On the other hand, aquaporin-4 is expressed in astrocyte feet in the brain-blood barrier and subventricular zones of the brain ventricles. Aquaporin-4 expression is high in cerebrospinal fluid in hydrocephalus. Furthermore, neuroepithelial denudation precedes noncommunicating hydrocephalus and this neuroepithelial disruption could allow aquaporin-4 to reach anomalous brain areas where it is unrecognized and induce the generation of aquaporin-4 antibodies which could cause the neuromyelitis optica and certain types of hydrocephalus.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2014-10-01 | International Scholarly Research Notices |