6533b7d2fe1ef96bd125e196
RESEARCH PRODUCT
Performance of existing definitions and tests for the diagnosis of invasive fungal diseases other than invasive candidiasis and invasive aspergillosis in critically ill, adult patients : a systematic review with qualitative evidence synthesis
Cornelia Lass-flörlDaniele Roberto GiacobbeValentina ZuccaroErika AspergesChiara RebuffiLuigia ScudellerToine MercierStijn BlotIlias KaraiskosDylan De LangeFrederic LamothMaddalena PeghinOliver A. CornelySofia TejadaAna Alastruey-izquierdosubject
diagnosis:infecciones bacterianas y micosis::micosis::infecciones fúngicas invasoras [ENFERMEDADES]invasive fungal diseasesPJPPlant ScienceAspergillosis:Bacterial Infections and Mycoses::Mycoses::Invasive Fungal Infections [DISEASES]law.invention0302 clinical medicineIFD; PJP; biomarker; diagnosis; invasive fungal diseases; pneumocystislawDiagnosis:Other subheadings::/diagnosis [Other subheadings]Medicine and Health Sciences030212 general & internal medicinelcsh:QH301-705.50303 health sciences:Natural Science Disciplines::Science::Research::Empirical Research::Qualitative Research [DISCIPLINES AND OCCUPATIONS]EcologyCommunicationPneumocystis jirovecii PneumoniaInvasive candidiasisIntensive care unitInvasive fungal diseasesSystematic reviewbiomarkerIFDMicrobiology (medical)medicine.medical_specialtyEvolutionQualitative evidence:Otros calificadores::/diagnóstico [Otros calificadores]pneumocystisInvestigació qualitativa03 medical and health sciencesBehavior and Systematics:disciplinas de las ciencias naturales::ciencia::investigación::investigación empírica::investigación cualitativa [DISCIPLINAS Y OCUPACIONES]medicineIntensive care medicineEcology Evolution Behavior and SystematicsAdult patients030306 microbiologyCritically illbusiness.industryPneumocystisBiomarker; Diagnosis; IFD; Invasive fungal diseases; PJP; PneumocystisBiomarkermedicine.diseaselnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]lcsh:Biology (General)Micosi - Diagnòsticbusinessdescription
Diagnòstic; Malalties fúngiques invasores; Pneumocystis Diagnóstico; Enfermedades fúngicas invasivas; Pneumocystis Diagnosis; Invasive fungal diseases; Pneumocystis The Fungal Infections Definitions in Intensive Care Unit (ICU) patients (FUNDICU) project aims to provide standard sets of definitions for invasive fungal diseases (IFDs) in critically ill, adult patients, including invasive aspergillosis (IA), invasive candidiasis (IC), Pneumocystis jirovecii pneumonia (PJP), and other non-IA, non-IC IFDs. The first step of the project was the conduction of separated systematic reviews of the characteristics and applicability to critically ill, adult patients outside classical populations at risk (hematology patients, solid organ transplant recipients) of available definitions and diagnostic tests for IFDs. We report here the results of two systematic reviews exploring the performance of available definitions and tests, for PJP and for other non-IA, non-IC IFDs. Starting from 2585 and 4584 records for PJP and other IFDs, respectively, 89 and 61 studies were deemed as eligible for full-text evaluation. However, only two studies for PJP and no studies for other IFDs met the FUNDICU protocol criteria for inclusion in qualitative synthesis. Currently, there is no sufficient solid data for directly evaluating the performance of existing definitions and laboratory tests for the diagnosis of PJP and other non-IA, non-IC IFDs in critically ill adult patients outside classical populations at risk. The present project did not require additional funding from routine research activities. Costs for open-access publications were covered by research funds of the main authors.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2021-02-28 |